Sherry, Barbara, Ph.D.
Professor of Virology College of Veterinary Medicine
Director of Genomic Sciences Graduate Programs
Phone: (919) 515-4480
Fax: (919) 515-3044
E-mail:
barbara_sherry@ncsu.edu
Research Area:
We
study reovirus-induced myocarditis (cardiac inflammation
and tissue damage) in mice as a model for this important
human disease. Recently, we have focused on the cardiac
response to viral infection, with particular emphasis on
viral induction of the antiviral cytokine
interferon-beta in cardiac cells. We are interested in
both the viral genes that stimulate this response, and
the cardiac transcription factors and antiviral proteins
that are central to protection against disease. Our
approaches, using primarily molecular techniques,
include the use of transgenic mice and primary cardiac
myocyte cell cultures. This research is funded primarily
by NIH.
We have also
received NIH funding to investigate the smallpox vaccine
and related poxviruses in an effort to determine the
basis for vaccine-associated cardiac adverse effects, in
collaboration with Dr. David Pickup at Duke University.
Our short-term goal is to identify strain-specific
effects on cardiac cells and the heart, towards
development of a safer vaccine.
Selected Publications:
Zurney J, Howard KE, Sherry B. Basal
expression levels of IFNAR and Jak-STAT components are
determinants of cell-type-specific differences in
cardiac antiviral responses. J Virol. 2007
Dec;81(24):13668-80.
This publication was selected as one of that issue's
"Spotlights", which are "Articles of Significant
Interest Selected from This Issue by the Editors" (http://jvi.asm.org/current.dtl)
O'Donnell, S.M., M.W. Hansberger, J.L. Connolly, J.D.
Chappell, M.J. Watson, J.M. Pierce, W. Han, E.S. Barton,
J.C. Forrest, T. Valyi-Nagy, F.E. Yull, T.S. Blackwell,
J.N. Rottman, B. Sherry, and T.S.
Dermody. Organ-specific roles for transcription factor
NF-kB in reovirus-induced apoptosis and disease. The
Journal of Clinical Investigation
115:2341-2350.
Stewart, M.J., K. Smoak, M.A. Blum, and B Sherry.
2005. Basal and reovirus-induced intereferon-b (IFN-b)
and IFN-b-stimulated gene expression are cell
type-specific in the cardiac protective response. J.
Virology 79(5):2979-2987.
DeBiasi R.L., B.A. Robinson, B. Sherry, R.
Bouchard, R.D. Brown, M. Rizeq, C. Long, and K. Tyler.
2004. Caspase inhibition protects against reovirus-induced
myocardial injury in vitro and in vivo. J. Virol. 78:
11040-11050.
Stewart, M.J., M.A. Blum, and B. Sherry. PKR's
protective role in viral myocarditis. Virology
314:92-100, 2003.
Azzam, K.M., D.L. Noah, M.J. Stewart, M.A. Blum, and
B. Sherry. Interferon regulatory factor-1,
interferon- and reovirus-induced myocarditis. Virology
298:20-29, 2002.
DeBiasi RL, Edelstein C, Sherry B, and Tyler KL:
Calpain inhibition protects against virus-induced
apoptotic myocardial injury. J. Virol. 75:351-361, 2001.
Noah DL, Azzam KM, Blum MA, and Sherry B:
Interferon regulatory factor-3 is required for viral
induction of interferon-b in primary cardiac myocyte
cultures but not L929 cells. J. Virol. 73:10208-10213,
1999.
Brentano L, Noah DL, Brown EG, and Sherry B: The
reovirus protein m2, encoded by the M1 gene, is an
RNA-binding protein. J. Virol. 72:8354-8357, 1998.
Sherry, B. The role of Interferon Regulatory
Factors in the cardiac response to viral infection.
Viral Immunology 15(1):17-28, 2002.
Sherry B, Torres J, and Blum MA: Reovirus induction
of and sensitivity to beta interferon in cardiac myocyte
cultures correlate with induction of myocarditis and are
determined by viral core proteins. J. Virol.
72:1314-1323, 1998.
Graduate Students:
Jennifer Zurney
Doctoral Student
Microbiology graduate program
Lianna Li
Doctoral Student
Functional Genomics graduate program
Susan Irvin
Doctoral Student
Comparative Biomedical Sciences graduate program
Other:
Lab Manager : Wrennie Edwards
wrennie_edwards@ncsu.edu
Undergraduate Research Student: Casey Andrason (Animal Science, CALS)
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